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## Hill Function |

The sequential steps for converting blood measurements to an input curve are explained in a dedicated section. The current plasma fraction model serves for converting a whole-blood activity curve into a plasma-activity curve.

It is assumed that a curve representing the measured fractions of plasma/whole-blood activity has been loaded with Load Plasma/WB Fraction.

Operational Model Curve

The Hill model allows replacing the tail of the fraction curve by an analytical function. The Begin parameter defines at what time the models switches from linear interpolation to the Hill function.

The illustration below shows an example with the Hill function fitted following 2 minutes (Begin = 120sec). The the weighting has been changed for putting more emphasis on the tail. Note that the linear interpolation assumes a fraction of 1 at t=0.

Parameter Fitting

The model supports the fitting of the parameters Begin, scale, A, B, C. Fitting is started with the Fit plasma fraction button, which only takes the samples after the Begin time into consideration.

Use without Measured Fraction

If no measured plasma/whole-blood fraction data is available, the Hill model can still be applied. In this case the Begin time is disregarded, and the functional defined by the entered parameters applied.

References

1.Gunn RN, Sargent PA, Bench CJ, Rabiner EA, Osman S, Pike VW, Hume SP, Grasby PM, Lammertsma AA: Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. Neuroimage 1998, 8(4):426-440. DOI