Please use the Load FUNCTIONAL button to load the functional PET series. The series may be static or dynamic.
In the case of a dynamic PET series the user should define the averaging range that will be used to create a new series, FUNCTIONAL AVG, which will be used for spatial normalization. Often, the early frames are perfusion-related and thus an average of these frames is better suited for normalization with the water PET template than later frames with a more specific uptake pattern.
The original and the averaged images are shown in a fusion rendering which can be controlled in the area below the controls of the individual images.
If the PET field-of-view is larger than the brain the data set should be reduced in order to save RAM and optimize processing. This can be achieved by enabling the Crop and the Auto boxes. It results in the placement of the yellow cropping box, which can be inspected by the user. Alternatively, the crop box can be set manually when the Auto box is disabled. Place the yellow crop box by clicking at the brain center. The brain should be fully enclosed. If this is not the case, the edge size in [mm] can be adjusted for each direction by selecting the size in the corresponding list.
Enable the Denoising box if the data are very noisy, in order to improve later steps such as matching and quantification. Inspect the dynamic series to identify motion, and optionally correct for it using the Motion correction setting.
To continue please select the None radio button (no anatomical reference available) and proceed using the Normalization action button.